Ca2+-induced opening of the mitochondrial permeability transition pore (MPTP) in cardiac mitochondria from rats fed either a standard low n-3 PUFA diet or supplemented with DHA, EPA or ALA at 2.3% of energy intake. Redrawn from data taken from [22] for the standard diet, DHA and EPA groups, and from unpublished data for the ALA group. ALA, alpha-linoleic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; MPTP, mitochondrial permeability transition pore; PUFA, polyunsaturated fatty acid.