. Author manuscript; available in PMC: 2014 Jun 23.

Published in final edited form as: Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):122–126. doi: 10.1097/MCO.0b013e32834fdaf7

Table 1.

KEY POINTS
Mitochondrial phospholipid composition differs greatly across species and tissue type and can be modified by dietary intake of fatty acids. In particular, n-3 PUFA supplementation can modulate mitochondrial phospholipid composition as evidenced through alterations of cardiolipin fatty acid side chains with intake of DHA. Mitochondrial phospholipid remodeling with n-3 PUFAs is further associated with mitochondrial function and delayed Ca²⁺-induced mitochondrial permeability transition pore (MPTP) opening. Dietary PUFAs may provide cardioprotective effects with various disease states through remodeling of mitochondrial membranes and improving mitochondrial function.

KEY POINTS

Mitochondrial phospholipid composition differs greatly across species and tissue type and can be modified by dietary intake of fatty acids.
In particular, n-3 PUFA supplementation can modulate mitochondrial phospholipid composition as evidenced through alterations of cardiolipin fatty acid side chains with intake of DHA.
Mitochondrial phospholipid remodeling with n-3 PUFAs is further associated with mitochondrial function and delayed Ca²⁺-induced mitochondrial permeability transition pore (MPTP) opening.
Dietary PUFAs may provide cardioprotective effects with various disease states through remodeling of mitochondrial membranes and improving mitochondrial function.