Jarid1b−/− mice exhibit reduced body weight and higher incidence of adult mortality.
A and B, weight of male (A) and female (B) Jarid1b+/+ and Jarid1b−/− mice of the indicated age. For males, n = 24 for Jarid1b+/+ and n = 23 for Jarid1b−/−; for females, n = 28 for Jarid1b+/+ and n = 40 for Jarid1b−/−. D, days; M, months. Error bars represent S.E. C and D, Kaplan-Meier survival curve of male (C) and female (D) Jarid1b+/+ and Jarid1b−/− animals. For males, n = 44 for Jarid1b+/+ and n = 58 for Jarid1b−/−; for females, n = 43 for Jarid1b+/+ and n = 67 for Jarid1b−/−. *, p < 0.05; **, p < 0.01.