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JARID1B is required for normal serum estrogen level. A, serum 17β-estradiol levels of Jarid1b+/+ and Jarid1b−/− females of the indicated age. E2, 17β-estradiol. For 5–6 weeks, n = 6 for each genotype; for 7–9 weeks, n = 5; for ≥3 months, n = 3. Error bars represent S.E. B, normalized uterine weights of Jarid1b+/+ and Jarid1b−/− animals of the indicated age. For 5–6 weeks, n = 8; for 7–9 weeks, n = 6. Error bars represent S.E. *, p < 0.05. wks, weeks.
