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. 2014 May 9;289(25):17658–17667. doi: 10.1074/jbc.M114.552158

FIGURE 8.

FIGURE 8.

Characterization of P2X4 currents in the plasma membrane. A, large P2X4 currents were induced by bath application of 0.1 mm ATP at neutral pH (pH 7.4) in COS1 cells expressing P2X4-GFP. B, little P2X4 current was detected with bath application of 0.1 mm ATP in an acidic (pH 4.6) solution. C, plasma membrane P2X4 was NMDG+ permeable. Large inward currents induced by 0.1 mm ATP when the external solution contained NMDG+ as the sole cation.