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SRC-2 control of PPARα may be mediated through GATA-4 and Tbx5. A, transactivation assay as described in Fig. 4B for luciferase driven by the PPARα promoter. B, qPCR analysis of mRNA expression for PPARα or the indicated targets as described in Fig. 2A for siRNA-mediated knockdown in H9c2 cells. Statistical analysis was performed with Student's t test where * = p ≤ 0.05, ** = p ≤ 0.01, and *** = p ≤ 0.001. NS indicates p > 0.05.
