FIGURE 5.

Ca²⁺ oscillations run down in the presence of caveolin-1-GFP (Cav1) under conditions of regenerative Ca²⁺ release. Cells were stimulated in Ca²⁺-free external solution supplemented with 1 mm La³⁺. A, whereas Ca²⁺ oscillations to LTC₄ in wild type cells are sustained, they run down quickly when caveolin-1-GFP is expressed (dotted line). B, aggregate data summarizing the number of oscillations per 100 s bin is shown. Each point is the mean between 23 and 41 cells from four independent experiments. C and D, the amplitude of the first Ca²⁺ oscillation (C) and the duration of each oscillation (D) are compared. ***, p < 0.001.