FIGURE 7.

Rundown of Ca²⁺ oscillations is not associated with inactivation of InsP₃ receptors. A and B, ATP (100 μm) was applied 600 s after stimulation with LTC₄ (in Ca²⁺-free solution containing 1 mm La³⁺) in either wild type cells (A) or in cells expressing caveolin-1-GFP (Cav1) (B). C, aggregate data from several experiments are compared. Each bar represents 21–35 cells from two independent experiments. Black bars denote responses to ATP in the absence of prior stimulation with LTC₄.