FIGURE 10.

ASN12 restores neurogenesis in the Line41 APPtg mouse. Line41 APPtg and non-tg mice received ASN12, SN5 (1 mg/kg), or saline intraperitoneally twice weekly for 3 weeks. A, brains were fixed in paraformaldehyde, and representative sections were stained for DCX or PCNA. B, analysis of tissue staining was completed by examining cell counts by stereology. ML, medial layer; GC, granular cells; SG- subgranular layer. * indicates statistical significance p < 0.05 compared with Non-tg controls. # indicates statistical significance p < 0.05 compared with vehicle or SN5-treated Line41 APPtg mice. Arrows indicate cells positive for CT-NPY or Y2-R staining. Arrows indicate cells positive for PCNA staining. Scale bars = 20 μm. n = 5 per group.