FIGURE 9.

ASN12 restores levels of C-terminal NPY fragment in the Line41 APPtg mouse. Line41 APPtg and non-tg mice received ASN12, SN5 (1 mg/kg) or saline intraperitoneally twice weekly for 3 weeks. A, brains were fixed in paraformaldehyde and representative sections were stained for full-length NPY (FL-NPY), C-terminal NPY (CT-NPY), or NPY Y2 receptor (Y2-R). B, analysis of tissue staining was completed by examining cell counts by stereology or total optical density. ML, medial layer; GC, granular cells; SG, subgranular layer. * indicates statistical significance p < 0.05 compared with non-tg controls. # indicates statistical significance p < 0.05 compared with vehicle or SN5-treated Line41 APPtg mice. Scale bars = 20 μm. n = 5 per group.