TABLE 1.
Pharmacokinetic parameters of ASN12 intravenous delivery to mice
Recombinant ASN12 was delivered by intravenous tail vein injection at 1 mg/kg to C57/Bl6, female, 6-month-old mice. PK calculations were made from the concentration versus time curves in Fig. 2. n = 3 per time point. ND means not determined. AUC mean area under the curve.
| Plasma | Brain | Liver | |
|---|---|---|---|
| AUC(0-inf) (ng/ml (or mg)·h) | 9438.8 | 29.28 | 398.12 |
| Clearance ng/h | 2.12 ng/h | ND | 50.23 ng/h |
| t½ | 7.51 h | 22.54 h | 7.00 h |
| Vd | 22.97 ml | ND | ND |
| % ID at 24 h | 0.29 | 1.70 | 37.23 |