Table 4. Genes down-regulated in atretic compared with healthy follicles.
| Gene Symbol | Fold Change | Gene Symbol | Fold Change | Gene Symbol | Fold Change |
| Cell cycle and DNA replication | |||||
| FAM64A | 7.3 | CKS2 | 4.0 | CENPP | 2.7 |
| UHRF1 | 7.0 | NCAPG | 4.0 | BRCA1 | 2.7 |
| CCNB1 | 7.0 | TPX2 | 3.9 | ORC1 | 2.6 |
| PTTG1 | 6.5 | CDCA7 | 3.9 | SMC4 | 2.6 |
| CDCA8 | 6.2 | CCDC99 | 3.8 | PCNA | 2.6 |
| CENPN | 5.8 | E2F8 | 3.8 | POLE2 | 2.6 |
| CDCA2 | 5.7 | SGOL1 | 3.8 | CHTF18 | 2.5 |
| RRM2 | 5.7 | OIP5 | 3.8 | SMC2 | 2.5 |
| HJURP | 5.6 | KIF4A | 3.8 | CKS1B | 2.5 |
| RAD51AP1 | 5.5 | FAM83D | 3.7 | MCM2 | 2.5 |
| CDK1 | 5.5 | KNTC1 | 3.6 | UBE2S | 2.4 |
| ASPM | 5.4 | CCNF | 3.6 | ATAD5 | 2.4 |
| TOP2A | 5.4 | ECT2 | 3.5 | CDT1 | 2.4 |
| CDCA5 | 5.4 | KIF22 | 3.5 | MCM5 | 2.4 |
| AURKB | 5.3 | AURKA | 3.5 | CHAF1B | 2.4 |
| CDCA3 | 5.3 | MAD2L1 | 3.4 | HMGB2 | 2.3 |
| ASF1B | 5.2 | MCM4 | 3.4 | PLK1 | 2.3 |
| ESPL1 | 5.2 | CHAF1A | 3.3 | RPA3 | 2.3 |
| BUB1 | 5.2 | KIFC1 | 3.3 | CCNE2 | 2.3 |
| CDC20 | 5.2 | SKA3 | 3.3 | BORA | 2.3 |
| CCNB2 | 5.1 | ERCC6L | 3.2 | PSRC1 | 2.3 |
| KIF20A | 5.1 | CDC6 | 3.2 | CENPO | 2.2 |
| NUSAP1 | 5.1 | STIL | 3.2 | NDE1 | 2.2 |
| KIF2C | 5.0 | RACGAP1 | 3.2 | GINS2 | 2.2 |
| CENPE | 5.0 | NCAPG2 | 3.2 | GINS3 | 2.2 |
| CASC5 | 5.0 | FANCI | 3.2 | MCM6 | 2.2 |
| SPC24 | 4.9 | DSN1 | 3.2 | STRA13 | 2.1 |
| SPAG5 | 4.8 | CKAP2 | 3.2 | MYBL2 | 2.1 |
| PRC1 | 4.7 | MCM3 | 3.1 | CDC25C | 2.1 |
| CCNA2 | 4.7 | ZWINT | 3.1 | RCC1 | 2.1 |
| CENPF | 4.7 | KIF23 | 3.0 | NCAPD3 | 2.0 |
| NCAPH | 4.6 | FEN1 | 2.9 | H2AFZ | 2.0 |
| MELK | 4.5 | H2AFX | 2.8 | RRM1 | 2.0 |
| SKA1 | 4.4 | CHEK1 | 2.8 | RPA2 | 2.0 |
| BUB1B | 4.2 | VRK1 | 2.7 | LIG1 | 2.0 |
| NDC80 | 4.2 | RMI2 | 2.7 | NSL1 | 2.0 |
| Cell Death | |||||
| BIRC5 | 5.7 | ||||
| Cell Morphology | |||||
| CKAP2L | 3.8 | ANLN | 2.9 | ||
| LMNB1 | 3.7 | NRM | 2.2 | ||
| Cytokines, Hormones and Receptors | |||||
| HMMR | 3.6 | CCL25 | 2.9 | FGFR2 | 2.3 |
| APLNR | 3.2 | VEGFA | 2.7 | ||
| Intercellular and Cell to Matrix Adhesion | |||||
| TROAP | 2.8 | PCDH7 | 2.1 | ||
| Ion Transport | |||||
| KCNMA1 | 3.3 | ||||
| Protein Trafficking | |||||
| KPNA2 | 3.7 | ||||
| RNA Processing | |||||
| DDX39A | 2.6 | MAGOHB | 2.1 | ||
| SRSF1 | 2.3 | LSM4 | 2.0 | ||
| Transcription Regulation | |||||
| TRIP13 | 3.8 | ARHGEF39 | 3.1 | EZH2 | 2.1 |
| TCF19 | 3.4 | MXD3 | 3.0 | ||
| Transport | |||||
| SLC16A1 | 2.3 | SLCO2A1 | 2.2 | AQP11 | 2.2 |
| Other Enzymes | |||||
| KIAA0101 | 7.0 | CYP11A1 | 2.5 | LIPG | 2.2 |
| UBE2C | 6.0 | TYMS | 2.4 | CYB5R3 | 2.2 |
| TK1 | 3.2 | DCK | 2.3 | PSAT1 | 2.1 |
| DTYMK | 3.1 | ACOT7 | 2.3 | PPA1 | 2.1 |
| HPGD | 3.0 | ASS1 | 2.2 | MTHFD1 | 2.0 |
| PHGDH | 2.7 | ALPL | 2.2 | BDH1 | 2.0 |
| DUT | 2.6 | CRYM | 2.2 | ||
| Other Signalling | |||||
| SHCBP1 | 5.8 | IQGAP3 | 2.7 | ||
| Other | |||||
| OIT3 | 3.9 | C11orf82 | 2.3 | RDM1 | 2.1 |
| TFF2 | 2.9 | S100A2 | 2.3 | CXorf69 | 2.1 |
| TMEM88 | 2.4 | PLIN5 | 2.2 | CCDC115 | 2.0 |
| C1orf112 | 2.4 | MANF | 2.2 | MRPL15 | 2.0 |
| HN1 | 2.3 | TAGLN3 | 2.2 | BCS1L | 2.0 |
| Non-IPA annotated genes | |||||
| CENP-A /// LOC782601 // | 5.2 | FBXO5 | 3.2 | FOXM1 | 2.1 |
| CENP-A /// CENP-A /// L | 3.9 | TUBA1A /// TUBA1B | 2.3 | ||
| TACC3 | 3.7 | LOC100138846 /// LOC784 | 2.1 | ||
≥2 fold-change with P<0.05 by Benjamini-Hochberg post-hoc test for multiple corrections following one-way ANOVA and categorized by function. Assignation of genes to categories was determined manually by the authors based on available information from NCBI databases and literature. Genes are listed in descending order of fold change within each category.