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. 2014 Jun 23;9(6):e100158. doi: 10.1371/journal.pone.0100158

Table 5. Adjusted all-cause mortality risk in population aged 45–64 in relation to the presence of the dyslipidaemias and the other cardiovascular risk factors (Kaunas urban population linked mortality file (1983–2008)).

Dyslipidaemias and other CVD risk factors combinations MEN WOMEN
HR (95% CI) HR (95% CI)
HDL cholesterol (HDL chol) and triglycerides (TG)
High HDL chol + normal TG 1 (Reference) 1 (Reference)
Reduced HDL chol or elevated TG 1.06 (0.89–1.27) 1.02 (0.79–1.32)
Reduced HDL chol + elevated TG 1.30 (1.001.68) 1.83 (1.262.66)
HDL chol, TG, and hypertension (AH)
No AH + high HDL chol + normal TG 1 (Reference) 1 (Reference)
No AH + (reduced HDL chol or elevated TG) 0.95 (0.72–1.26) 1.39 (0.90–2.13)
AH + (reduced HDL chol or elevated TG) 1.30 (1.051.61) 1.49 (1.112.01)
AH + reduced HDL chol + elevated TG 1.71 (1.232.38) 2.56 (1.614.05)
HDL chol, TG and fasting glucose (FG)
Normal FG + high HDL chol + normal TG 1 (Reference) 1 (Reference)
Normal FG + (reduced HDL chol or elevated TG) 1.08 (0.90–1.30) 1.11 (0.86–1.45)
High FG + (reduced HDL chol or elevated TG) 0.87 (0.68–1.13) 1.71 (1.202.44)
High FG + reduced HDL chol + elevated TG 1.76 (1.142.71) 4.43 (2.727.20)
HDL chol, TG and smoking status
Never smokers + high HDL chol + normal TG 1 (Reference) 1 (Reference)
Never smokers + (reduced HDL chol or elevated TG) 1.03 (0.77–1.38) 1.07 (0.83–1.38)
Smoking + (reduced HDL chol or elevated TG) 1.57 (1.261.96) 1.21 (0.75–1.94)
Smoking + (reduced HDL chol + elevated TG) 1.89 (1.342.66) 1.25 (0.30–5.17)
HDL chol, TG, and obesity
No obesity + high HDL chol + normal TG 1 (Reference) 1 (Reference)
No obesity + (reduced HDL chol or elevated TG) 1.00 (0.81–1.24) 1.14 (0.76–1.71)
Obesity + (reduced HDL chol or elevated TG) 1.23 (0.95–1.60) 1.17 (0.82–1.67)
Obesity + reduced HDL chol + elevated TG 1.11 (0.76–1.61) 2.25 (1.423.55)

HR adjusted by age, study survey year, education, BMI, total cholesterol level, triglycerides level, HDL cholesterol level, blood pressure, AH, FG level, smoking and physical activity habits.

Abbreviations: CI - confidence interval; BMI – body mass index; HR - Hazard ratio; SBP – systolic blood pressure; DBP - diastolic blood pressure; FG - fasting glucose; TG – triglycerides; High HDL chol - High density lipoprotein cholesterol ≥1.03 mmol/L; Reduced HDL chol - High density lipoprotein cholesterol <1.03 mmol/L; Normal TG – triglycerides <1.70 mmol/L; Elevated TG - triglycerides ≥1.70 mmol/L; Normal FG - fasting glucose level <6.10 mmol/L; High FG - fasting glucose level ≥6.10 mmol/L; No AH – no arterial hypertension (SBP <140 and/or DBP <90 mm Hg); AH - arterial hypertension (SBP ≥140 and/or DBP ≥90 mm Hg and/or take medication for high blood pressure for at least 2 weeks); No obesity – BMI <30.0 kg/m2; Obesity - BMI ≥30.0 kg/m2.