Table 2. Genes overexpressed in the most discriminative pathways distinguishing different types of gliomas.
| Gene | OD | AS | GBM | Signaling Pathways | Annotation |
| ANGPT2 | 0 | 0 | 1 | PI3K-Akt | Angiopoietin-2 |
| CAV1 | 0 | 0 | 1 | Focal Adh. | Caveolin |
| COL1A1 | 0 | 0 | 1 | ECM, Focal Adh., PI3K-Akt | Collagen alpha-1(I) chain |
| COL4A2 | 0 | 0 | 1 | ECM, Focal Adh., PI3K-Akt | Canstatin |
| COL5A2 | 0 | 0 | 1 | ECM, Focal Adh., PI3K-Akt | Collagen alpha-2(V) chain |
| FN1 | 0 | 0 | 1 | ECM, Focal Adh., PI3K-Akt | Ugl-Y3 |
| LAMB1 | 0 | 0 | 1 | ECM, Focal Adh., PI3K-Akt | Laminin subunit beta-1 |
| LAMC1 | 0 | 0 | 1 | ECM, Focal Adh., PI3K-Akt | Laminin subunit gamma-1 |
| VEGFA | 0 | 0 | 1 | Focal Adh., PI3K-Akt, VEGF | Vascular endothelial growth factor A |
| RELA | 0 | 1 | 0 | PI3K-Akt | Transcription factor p65 |
| TGFB1 | 0 | 1 | 0 | TGF-Beta | Transforming growth factor beta-1 |
| CDK2 | 0 | 1 | 1 | PI3K-Akt | Cyclin-dependent kinase 2 |
| COL1A2 | 0 | 1 | 1 | ECM, Focal Adh., PI3K-Akt | Collagen alpha-2(I) chain |
| COL4A1 | 0 | 1 | 1 | ECM, Focal Adh., PI3K-Akt | Collagen alpha-1(IV) chain |
| LAMB2 | 0 | 1 | 1 | ECM, Focal Adh., PI3K-Akt | Laminin subunit gamma-1 |
| TLR2 | 0 | 1 | 1 | PI3K-Akt | Toll-like receptor 2 |
| BMP7 | 1 | 0 | 0 | TGF-Beta | Bone morphogenetic protein 7 |
| NOG | 1 | 0 | 0 | TGF-Beta | Noggin |
| NOTCH1 | 1 | 0 | 0 | Notch | Neurogenic locus notch homolog protein 1 |
| PGF | 1 | 0 | 0 | Focal Adh., PI3K-Akt | Placenta growth factor |
| RFC4 | 1 | 0 | 0 | DNA Repair, Telomere | Replication factor C subunit 4 |
| RFC5 | 1 | 0 | 0 | DNA Repair, Telomere | Replication factor C subunit 5 |
| RUVBL1 | 1 | 0 | 0 | Telomere | RuvB-like 1 |
| BMP2 | 1 | 1 | 0 | TGF-Beta | Bone morphogenetic protein 2 |
| CBLB | 1 | 1 | 0 | TGF-Beta | E3 ubiquitin-protein ligase CBL-B |
| DDIT4 | 1 | 1 | 0 | PI3K-Akt | DNA damage-inducible transcript 4 protein |
| DLL3 | 1 | 1 | 0 | Notch | Delta-like protein 3 |
| E2F5 | 1 | 1 | 0 | TGF-Beta | Transcription factor E2F5 |
| ID1 | 1 | 1 | 0 | TGF-Beta | DNA-binding protein inhibitor ID-1 |
| ID4 | 1 | 1 | 0 | TGF-Beta | DNA-binding protein inhibitor ID-4 |
| MAML2 | 1 | 1 | 0 | Notch | Mastermind-like protein 2 |
| CD44 | 1 | 1 | 1 | ECM | CD44 antigen |
| CDK4 | 1 | 1 | 1 | PI3K-Akt | Highly similar to Cell division protein kinase 4 |
| COL3A1 | 1 | 1 | 1 | ECM, Focal Adh., PI3K-Akt | Collagen alpha-1(III) chain |
| DTX3L | 1 | 1 | 1 | Notch | E3 ubiquitin-protein ligase DTX3L |
| EIF4EBP1 | 1 | 1 | 1 | PI3K-Akt, TGF-Beta | Euk. transl. initiation factor 4E-binding protein 1 |
| F2R | 1 | 1 | 1 | PI3K-Akt | Proteinase-activated receptor 1 |
| ID3 | 1 | 1 | 1 | TGF-Beta | DNA-binding protein inhibitor ID-3 |
| MYC | 1 | 1 | 1 | PI3K-Akt, TGF-Beta | Myc proto-oncogene protein |
| TNC | 1 | 1 | 1 | ECM, Focal Adh., PI3K-Akt | Tenascin |
| TP53 | 1 | 1 | 1 | PI3K-Akt | Cellular tumor antigen p53 |
Overexpressed genes representing the most discriminative cancer signaling pathways distinguishing oligodendrogliomas (OD), astrocytomas (AS) and glioblastomas (GBM) at the level of the top 300 genes (Figure 6). Genes identified as overexpressed in a specific glioma type are indicated by ‘1’, otherwise ‘0’. The column ‘Signaling Pathways’ represents the corresponding membership of each gene in one or more of these pathways.