Table 1. Acyl/desacyl ghrelin plasma ratio after intraperitoneal injection of LPS.
Treatmenta | Acyl/desacyl ghrelin plasma ratio | ||||
---|---|---|---|---|---|
0h | 2h | 5h | 7h | 24h | |
Vehicle | 1:3 | 1:3 | 1:3 | 1:3 | 1:4 |
LPS | 1:3 | 1:5* | 1:3 | 1:2 | 1:3 |
Overnight fasted rats were injected ip with LPS (100μg/kg body weight) or vehicle (pyrogen-free saline) and acyl and total ghrelin levels were assessed before, and at 2, 5, 7 and 24h post injection. Desacyl ghrelin levels were obtained by calculating the difference between total and acyl ghrelin. The acyl/desacyl ghrelin ratio was calculated from the mean values of 5 rats/group; p < 0.05 vs. vehicle.