Table 2. LPS decreases food intake in rats.
Treatmenta | Food intake/period (g/300g body weight) | |||
---|---|---|---|---|
1.5-2h | 2-5h | 5-7h | 7-24h | |
Vehicle | 4.8 ± 0.3 | 2.5 ± 0.7 | 4.6 ± 0.4 | 20.9 ± 0.9 |
LPS | 2.0 ± 0.6*** | 1.8 ± 0.4 | 3.1 ± 0.5* | 16.8 ± 0.9** |
Overnight fasted rats were injected ip with LPS (100μg/kg body weight) or vehicle (saline) and re-fed at 1.5h post injection. Food intake was monitored at 2, 5, 7 and 24h post injection and expressed as food intake/period (g/300g bw). Each line represents the mean ± sem of 7-8 rats/group.
p < 0.05,
p < 0.01 and
p < 0.001 vs. vehicle.