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. 2014 Jun 23;9(6):e100622. doi: 10.1371/journal.pone.0100622

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© 2014 Dimitrijevic et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Six canonical hotspots for isoAsp formation are indicated with carets (∧). Color-coding indicates regions of β-sheet (blue), α-helix (magenta), and turns (yellow) as deduced from crystal structure data according to the ExPASY (www.expasy.org) alignment application. Mouse is not color-coded because there is no crystal structure for mouse CKB. The dashed box encloses the acidic EED triplet essential for enzymatic activity.