Table 1. Comparison of phenotypes of PIMT-KO and CKB-KO mice, relative to wild type mice.
| Characteristic | PIMT-KO | CKB-KOa |
| Habituation: thigmotaxisb | “hyperactivity in the open-field test” and “a strong thigmotaxic movement pattern” (Vitali and Clarke, 2004) | “diminished open-field habituation” and “none of the (KO) mice created a home-base” |
| Learning: Morris water maze | “impaired spatial memory” (Ikegaya et al., 2001) | “slower to learn, but acquired the spatial task” |
| Epileptic seizures | Highly susceptible. Spontaneous fatal seizures at 1–3 mo. (Kim et al., 1997) | In response to pentylentetrazole, the KO mice “showed significantly more myoclonic jerks preceding the first seizure…and between the first and second seizures.” |
| Coordination: accelerating rotarod | “perform significantly better than their heterozygous and wild type litter-mates' (Vitali and Clarke, 2004) | “did not differ from wild type mice in their motor coordination and balance on the rotarod” |
| Hippocampal histology | “increased cell proliferation and granule cell number in the dendate gyrus” (Farrar et al., 2005) | “intra- and infra-pyramidyl mossy fiber field is larger in (KO) mice” |
a
All of these entries are from Jost et al., 2002.
b
A taxis in which contact, especially with a solid body, is the directive factor.