Figure 2. Immunization with OMVs increased mouse survival in a sepsis model.

(A) The survival of mice that were challenged with different numbers of colony forming units of A. baumannii was observed; (B) Mice that were actively vaccinated with OMVs had a higher survival rate than the control mice in response to the A. baumannii challenge 11 days after the last immunization; (C) Mice that passively received antiserum were completely protected from A. baumannii infection; there were no deaths in the subsequent 2 weeks. Mice were injected intraperitoneally with 50 µL of live Ab1 (1.1×10⁶ CFU/mL) mixed (1∶1, v/v) with 10% porcine mucin (w/v) in both the active and passive immunization approaches. The p value was determined by the non-parametric log-rank test. **, p<0.01, ***, p<0.001; n = 12 to 15 mice per group.