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. 2014 Jun 23;9(6):e100609. doi: 10.1371/journal.pone.0100609

Figure 4. Mitochondrial leak respiration and respiratory control ratios (RCR) of ob/ob and lean livers following different duration of cold ischaemia (hours).

Figure 4

A: Ob/ob livers showed increased mitochondrial leak rates with progressive cold ischaemia and increased significantly after 16 hours of cold ischaemia, while lean liver mitochondrial leak rates remained stable. B: Ob/ob livers consistently showed lower RCRs compared to lean livers and differed significantly after 16 hours of cold ischaemia. Ob/ob livers also demonstrated decreased RCR after 16 hours of cold ischaemia relative to 1.5 hours while lean liver RCR remained stable. Data are shown as mean ± SEM (n = 9 mice/group; ob/ob, closed circle; lean livers, open circle). Restricted maximum likelihood with post-hoc Tukey-Kramer analysis was performed. *, P<0.05 (vs. lean); #, P<0.01 (vs. 1.5 hours).