Table 1.
CGM measures of glycemic control and variability among Ab+ versus Ab− subjects and among Ab+ progressors versus Ab+ nonprogressors
| Variables | Ab+ subjects n = 14 | Ab− subjects n = 9 | P value | Ab+ progressors n = 5 | Ab+ nonprogressors n = 9 | P value |
|---|---|---|---|---|---|---|
| Age, years | 13.8 ± 3.5 | 13.6 ± 2.0 | 0.88 | 11.7 ± 2.3 | 14.9 ± 3.6 | 0.08 |
| Mean glucose, mg/dL | 117 ± 13 | 109 ± 11 | 0.07 | 125 ± 16 | 112 ± 8 | 0.19 |
| Mean day† glucose, mg/dL | 119 ± 13 | 109 ± 11 | 0.06 | 129 ± 15 | 114 ± 8 | 0.06 |
| Mean night glucose, mg/dL | 111 ± 16 | 111 ± 15 | 0.98 | 115 ± 22 | 109 ± 12 | 0.52 |
| Maximum day† glucose value, mg/dL | 221 ± 53 | 168 ± 31 | 0.011 | 241 ± 38 | 210 ± 58 | 0.44 |
| Maximum night glucose value, mg/dL | 173 ± 35 | 170 ± 44 | 0.57 | 185 ± 34 | 166 ± 36 | 0.36 |
| SD, mg/dL | 26 ± 8 | 19 ± 7 | 0.039 | 32 ± 7 | 23 ± 7 | 0.06 |
| CV, mg/dL | 22 ± 6 | 17 ± 5 | 0.046 | 26 ± 5 | 20 ± 6 | 0.15 |
| Range, mg/dL | 166 ± 53 | 111 ± 43 | 0.016 | 182 ± 37 | 157 ± 60 | 0.3 |
| % Time ≥140 mg/dL | 0.18 ± 0.15 | 0.09 ± 0.09 | 0.04 | 0.31 ± 0.18 | 0.12 ± 0.07 | 0.04 |
| % Time ≥200 mg/dL | 0.02 ± 0.03 | 0 ± 0.01 | 0.075 | 0.03 ± 0.04 | 0.01 ± 0.01 | 0.06 |
| AUC,‡ mg/min/dL | 676,196 ± 72,197 | 627,443 ± 64,823 | 0.16 | 725,629 ± 91,052 | 648,733 ± 44,149 | 0.15 |
| AUC‡ day,† mg/min/dL | 514,433 ± 54,758 | 466,436 ± 48,577 | 0.06 | 561,040 ± 61,792 | 488,540 ± 29,180 | 0.02 |
| AUC‡ night, mg/min/dL | 160,977 ± 22,912 | 158,913 ± 22,308 | 0.60 | 164,180 ± 32,128 | 159,198 ± 18,082 | 0.52 |
| HbA1c, % (mmol/mol) | 5.5 ± 0.8 (37 ± 8.7) | NA | NA | 5.9 ± 0.3 (41 ± 3.3) | 5.3 ± 0.9 (34 ± 9.8) | 0.16 |
Values are mean ± SD. NA, HbA1c not done in Ab− subjects.
†Day values are between 6:00 a.m. and midnight.
‡AUC calculated by the trapezoidal rule.