Table 4.
Multivariable models for PFS and OS by baseline and response characteristics
| Characteristic | Median PFS (mos) | HR (95% CI) | P | Median OS (mos) | HR (95% CI) | P |
|---|---|---|---|---|---|---|
| Absence of del(17p) | NR | 0.08 (0.02-0.3) | <.001 | NR | 0.2 (0.04-0.7) | .02 |
| CR | NR | 0.2 (0.05-0.6) | .007 | NR | 0.7 (0.5-0.9) | .05 |
| Overall remission | NR | 0.1 (0.03-0.5) | .003 | NR | NS | NS |
| MRD response-negative | NR | 0.1 (0.01-0.8) | .03 | NR | 0.6 (0.4-0.9) | .02 |
The HRs were adjusted from the multivariable Cox regression model. Variables not significant (P > .05) on MVA for PFS: age ≥65 years; B2M ≥4 mg/L; unmutated IGHV gene; ZAP70 positive. Variables not significant (P > .05) on MVA for OS: age ≥65 years; B2M ≥4 mg/L; overall remission.
mos, months NR, not reached; NS, not significant.