Table 5.

Landmark MVA for PFS and OS by baseline and response characteristics

Characteristic	Median PFS (mos)	HR (95% CI)	P	Median OS (mos)	HR (95% CI)	P
Absence of del(17p)	NR	0.05 (0.01-0.2)	<.001	NR	0.3 (0.09-0.9)	.05
CR	NR	0.2 (0.05-0.9)	.04	NR	0.3 (0.1-0.8)	.02
MRD response-negative	NR	0.1 (0.01-0.9)	.04	NR	0.7 (0.5-0.9)	.05

The HRs were adjusted from the multivariable Cox regression model. Variables not significant (P > .05) on MVA for PFS: age ≥65 years; B2M ≥4 mg/L; unmutated IGHV gene; ZAP70 positive; overall remission. Variables not significant (P > .05) on MVA for OS: age ≥65 years; B2M ≥4 mg/L; overall remission.

mos, months; NR, not reached.