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. Author manuscript; available in PMC: 2014 Jun 24.
Published in final edited form as: Mol Immunol. 2010 Nov 18;48(4):431–441. doi: 10.1016/j.molimm.2010.09.016

Fig. 5. Model for the hypoallergenic behavior of rBet v 1 trimer.

Fig. 5

Bet v 1 molecules in their monomeric form (A: rBet v 1) or as aggregated trimer (B: Trimer) can bind a comparable number of IgE antibodies in solution. However, monomeric rBet v 1 molecules may be more efficient in cross-linking of effector cell-bound IgE (C) than the aggregated trimer (D). IgE epitopes on monomeric forms of Bet v 1 can be well accessed by effector cell-bound IgE whereas only a certain portion of the IgE epitopes on the aggregated trimers comes into an optimal position for cross-linking of effector cell-bound IgE.