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. 2014 Jun 6;193(1):439–451. doi: 10.4049/jimmunol.1301497

FIGURE 6.

FIGURE 6.

Increased epithelial proliferation in response to luminal microbial input is abrogated in MyD88-deficient mice, along with a lack of 7/4+ cell recruitment to the stem cell niche and surface epithelium. (A) Total BrdU incorporation in MyD88-deficient mice following luminal stimulation with LPS or E. coli was the same as in control-treated mucosal explants (n = 3). There was no change in 7/4+ (B), Ly6C+ (C), or F4/80+ (D) cell numbers in the colonic mucosa and a lack of recruitment to the base or top crypt epithelium (E and F) in MyD88-deficient mice (n = 3) following apical LPS, MDP, or E. coli treatment. (G) Total BrdU incorporation in villin cre MyD88–deficient mice following luminal stimulation with LPS, MDP, or E. coli was the same as in control-treated mucosal explants (n = 3). There was no change in 7/4+ (H) or Ly6C+ (I) cell numbers in the colonic mucosa, and there was a lack of recruitment to the base or top crypt epithelium (J and K) in villin cre MyD88–deficient mice (n = 3) following apical LPS, MDP, or E. coli treatment. Data are mean ± SEM.