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. 2014 Jun 13;12:50. doi: 10.1186/1477-7827-12-50

Figure 5.

Figure 5

STAT1 as an integral factor of IGF, HGF, EGF, IL-6, and PDGF signaling pathways. STAT1, 3, and 5 are primarily activated by growth factors and regulate proliferation and apoptosis. A number of growth factors are known to contribute to the increased proliferative potential of cells derived from endometriotic lesions. The effects of such factors as EGF, PDGF, FGFR, IL-6, HGF and VEGF are all primarily achieved through STAT activation.