Figure 6.

Power of Exome Chip Study versus Exome Sequencing Study in the Finns

The comparison was done under M4 with SKAT-O. Because different genes are likely to have different pleiotropic effects and are therefore exposed to different strengths of purifying selection, M4 was generated to represent a potentially more realistic scenario. The top two lines show power comparison at a fixed sample size; the bottom two lines show power comparison at a fixed cost (and thus only one-tenth of the samples were sequenced). For both exome chip and exome sequencing studies, means and SDs of power were calculated on the basis of 20 simulated data sets.