Figure 1.

Color Fundus Photographs, Fundus Autofluorescence Images, and Foveal Optical Coherence Tomographs of the Right Eyes of Subjects CD1, CD2, CD3, and CD5

Images from subjects CD1 (aged 35 years; A), CD2 (aged 45 years; B), and CD5 (aged 53 years; D) are highly similar. Fundus autofluorescence imaging revealed a high-density concentric perifoveal ring surrounding irregular foveal autofluorescence in subjects CD1, CD2, and CD5; outside this ring, normal signal was observed (A, B, and D). In subject CD3 (aged 46 years; C), hypoautofluorescent patches were noted in the fovea and parafovea; this was combined with irregular autofluorescence outside the foveal region, suggesting more generalized retinal pigment epithelial dysfunction (C). Optical coherence tomography revealed abnormalities consistent with photoreceptor loss; they were either confined to the foveal region (subjects CD1, CD2, and CD5) or observed throughout the scan (subject CD3). Scale bars represent 200 μm.