Table 2.
Genome-wide Significant SNPs from the Three Approaches: Univariate Phenotypes, Univariate PCs, and Combined PCs Approach
| SNP ID | Chr | Genea | MAF | Rsq |
p Value |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACVn | FIB | FVIII | aPTT | vWF | PC1 | PC2 | PC3 | PC4 | PC5 | combPC | |||||
| rs6025 | 1 | F5 | 0.90 | 0.93 | 5.3 × 10−23∗ | – | – | – | – | 0.21 | 0.0091 | 1.1 × 10−17 | – | – | 1.8 × 10−18 |
| rs710446 | 3 | KNG1 | 0.54 | 0.99 | – | – | – | 5.2 × 10−11∗ | – | 0.064 | 0.0083 | – | 8.2 × 10−8 | – | 3.3 × 10−10 |
| rs1801020 | 5 | F12 | 0.78 | 0.86 | 0.29 | 0.19 | – | 2.2 × 10−12 | – | – | 1.0 × 10−5 | 0.0057 | 5.8 × 10−9 | – | 7.6 × 10−15∗ |
| rs576123 | 9 | ABO | 0.55 | 0.86 | – | – | 2.7 × 10−9 | 9.7 × 10−5 | 1.1 × 10−13 | 3.6 × 10−10 | 0.00011 | – | 0.0062 | – | 1.2 × 10−14∗ |
| rs76854392 | 10 | NRP1 | 0.90 | 0.74 | – | – | 6.6 × 10−7 | – | 0.0073 | 0.00075 | – | 0.029 | 0.28 | 0.00034 | 5.8 × 10−8∗ |
| rs191945075 | 11 | LRP4 | 0.96 | 0.60 | 2.8 × 10−25∗ | 0.095 | – | – | – | 0.017 | 0.00072 | 1.5 × 10−17 | – | – | 1.3 × 10−19 |
| rs183013917 | 18 | DCC | 0.99 | 0.82 | – | – | 1.7 × 10−7 | – | 0.035 | 0.0017 | – | – | 0.12 | 7.0 × 10−6 | 1.8 × 10−8∗ |
Abbreviations are as follows: Chr, chromosome; MAF, minor allele frequency; Rsq, quality control imputation criterion; FIB, Fibrinogen; FVIII, factor VIII; vWF, von Willebrand factor; aPTT, the activated partial thromboplastin time; ACVn, the standardized Anticoagulant response to Agkistrodon contortrix venom; combPC, combined PCs approach.
The p values for univariate raw phenotype analysis and univariate PC analysis were adjusted for multiple tests via the Bonferroni correction. p values greater than 0.3 were replaced by a dash “–.” The most significant test is indicated with an asterisk (∗).
a
Physically closest gene.