Table 2.
Cost data used in the model, including references and upper and lower bounds used in sensitivity analysis
| Procedures/health states | Costs (UK £) |
Definition information/source reference | Sensitivity analysis |
|
|---|---|---|---|---|
| Low | High | |||
| Procedures (total cost) | ||||
| Biopsy | 528 | NHS 2010–2011 Reference costs (DoH)—HRG GB04 (HRG codes to groups); sensitivity parameters informed by Lin et al. [38]; inflated to 2012 prices) |
188.30 | 882.26 |
| Fibroscan | 20.41 | Appendix two of the economic report from Stamuli et al. [40] (inflated to 2012 prices) |
13.00 | 35.48 |
| AFP and USS | 62.60 | AFP = £4; USS = £50, total = £54 [39] inflated to 2012 value [c × (1 + d)^t] |
33.43 | 128.65 |
| CT scan | 220.52 | HTA Thompson Coon et al. [39] inflated to 2012 £ plus £93 NHS tariff cost of Gastroenterology outpatient appointment |
152.70 | 266.27 |
| Ablation | 654.00 | NHS 2010/11 Reference cost: all OPSC codes = HRG group GB01 |
597.00 | 703.00 |
| Resection | 1,187.00 | NHS Reference costs 2010/11 code GA05 | 988.00 | 1,324.00 |
| Transplant | 16,377 | NHS 2010/11 Reference costs | 15,998.00 | 18,540.00 |
| Health state (attributable annual costs) | ||||
| Chronic HCV without cirrhosis | 0 | Assumption: no additional costs in this state; Cost of one medical physician (gastroenterology or infectious disease) out-patient appointment is £93 |
0 | 93.00 |
| Compensated cirrhosis | 1,357.51 | HTA Thompson Coon et al. [39], see also Hartwell et al. [41], Shepherd et al. [46] and Hospital and staff inflation index |
857.33 | 1,939.14 |
| First episode of decompensation (transition cost) |
2,512.00 | NHS 2011/12 tariff cost for episode of decompensated cirrhosis |
2,398.00 | 2,600.00 |
| Decompensated cirrhosis | 11,582.59 | HTA Thompson Coon et al. [39], Hartwell et al. [41], Shepherd et al. [46], Hospital community Staff inflation index |
7,650.12 | 14,761.42 |
| HCC without cirrhosis | 1,425.90 | Thompson Coon et al. [39]; inflated; assumed no extra cost as no cirrhosis |
734.31 | 2,461.19 |
| HCC in compensated cirrhosis | 2,587.51 | Thompson Coon et al. [39] (HTA) cost of HCC UK £1,425.90 (1,230/year INLATED) ? compensated cirrhosis 1,357.51/year |
2,091.82 | 3,818.70 |
| HCC in decompensated cirrhosis—not incl. decompensation costs |
13,008.50 | HTA Thompson Coon et al. [39], inflated. 11,582.59 ? 1,425.90 |
8,384.43 | 17,222.61 |
| Following successful resection or ablation | 4,094.56 | Thompson Coon et al. [39] inflated to 2012 UK £ | 2,782.22 | 5,669.39 |
| Transplant recipient | 1,759.60 | Thompson Coon et al. [39], Hartwell et al. [41], Shepherd et al. [46]; inflated |
976.99 | 2,754.55 |
| HCC recurrence | 5,520.46 | Cost of HCC plus cost of PRA state Thompson Coon et al. [39] HTA |
3,516.53 | 8,130.58 |
| Annual cost of palliative care | 35,765.64 | Cost of 1 year supply of Sorafanib from NICE technology appraisal 2010; additional palliative care/end of life costs not added |
35,200.00 | 36,000.00 |
AFP Serum alpha-fetoprotein, USS ultrasound scanning, CT computed tomography, NHS UK National Health Service