Table 3.
Associations with clinical-imaging dissociation (C-ID) in all subjects with an acute lacunar infarct on DWI (n = 72)
| C-ID (n = 22) | No C-ID (n = 50) | Univariate statistic and test score | Univariate p value | Multivariate p value | Multivariate OR (95% CI) | |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, years | 75 ±10 | 69 ± 11 | Student's t test −2.33 | 0.03 | 0.01 | 1.16 (1.03–1.30)1 |
| Gender, male (%) | 14 (64) | 27 (54) | χ2 0.58 | 0.45 | 0.09 | 5.25 (0.78–35.41) |
| Medical history | ||||||
| Previous stroke, % | 6 (27) | 8 (16) | χ2 1.24 | 0.27 | 0.64 | 1.66 (0.20–13.82) |
| Hypertension, % | 18 (82) | 22 (44) | χ2 8.85 | 0.004 | 0.12 | 3.72 (0.72–19.28) |
| Diabetes, % | 6 (27) | 4 (8) | χ2 4.75 | 0.06 | 0.02 | 17.1 (1.49–195.16) |
| Clinical | ||||||
| Median days, onset to assessment | 18 | 14 | Mann-Whitney −6 | 0.04 | 0.49 | 1.05 (0.91–1.21) |
| Range (IQR) | 1–97 (14–23) | 0–134 (3–22) | ||||
| Median days, onset to MRI | 27 | 20 | Mann-Whitney −6 | 0.04 | 0.76 | 0.98 (0.84–1.13) |
| Range (IQR) | 6–97 (16–32) | 0–141 (6–29) | ||||
| MR brain imaging characteristics | ||||||
| Subcortical infarct close to cortex, % | 16 (73) | 15 (30) | χ2 11.4 | 0.001 | 0.02 | 14.5 (1.61–130.1) |
| Infarct size, mm | 11.7±3.4 | 10.8±4.3 | Student's t test −1.01 | 0.32 | 0.99 | 1.00 (0.82–1.23) |
| Left hemisphere location, % | 15 (68) | 26 (52) | χ2 1.22 | 0.27 | 0.03 | 8.95 (1.23–64.99) |
| WMH 2–3, %a | 12 (55) | 20 (40) | χ2 1.31 | 0.25 | 0.43 | 0.48 (0.08–2.93) |
| EPVS 2–4, %b | 14 (64) | 25 (49) | χ2 0.98 | 0.32 | 0.67 | 1.52 (0.22–10.46) |
| Brain tissue loss 2–3, %c | 7 (32) | 9 (18) | χ2 1.69 | 0.19 | 0.35 | 0.30 (0.02–3.75) |
| Old stroke lesions, % | 14 (64) | 23 (46) | χ2 1.9 | 0.17 | 0.13 | 0.20 (0.02–1.65) |
EPVS = Enlarged perivascular spaces; WMH = white matter hyperintensities; IQR = interquartile range; OR = odds ratio; CI = confidence interval.
1
Odds ratio (OR) per additional year of age.
a
On Fazekas scale.
b
On EPVS scale.
c
On brain tissue loss scale.