Table 1.

Proestrous and diestrous GT-tg mice treated i.p. for 7 days with saline as a control or doxycycline (100 mg/kg) to induce HIV-1 Tat protein were assessed for motor behavior (movement velocity, total arm entries) and anxiety-like behavior (latency to enter the brightly-lit center, % time spent on brightly-lit open arms) in an open field and elevated plus, respectively.

		Proestrous		Diestrous
		Saline (n=20)	Doxycycline (n=20)	Saline (n=20)	Doxycycline (n=20)
Motor Measures
Movement Velocity (cm / s ± SEM)		7.2 ± 0.3	6.1 ± 0.2	6.5 ± 0.3	6.6 ± 0.4
Total Arm Entries (mean ± SEM)		20 ± 1	16 ± 1	18 ± 1	21 ± 4
Anxiety-like Measures
Latency to Central Entry (s ± SEM)		30 ± 5	60 ± 16*	50 ± 12†	97 ± 20*†
% Open Arm Time (% ± SEM)		36 ± 2	32 ± 2*	32 ± 2†	22 ± 3*†

A main effect for doxycycline condition indicates groups significantly differ from saline treatment(*), irrespective of estrous cycle phase.

A main effect for estrous cycle phase indicates groups significantly differ from proestrous mice (†), irrespective of doxycycline treatment, p < 0.05.