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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Bioorg Med Chem. 2014 Mar 24;22(9):2791–2798. doi: 10.1016/j.bmc.2014.03.014

Table 1.

Evaluation of triazole phosphonates against GGDPS and related enzymes.

Compound GGDPS
IC50 (µM)		 FDPS
IC50 (µM)		 FTase
IC50 (µM)		 GGTase I
IC50 (µM)		 GGTase II
IC50 (µM)
1 2.2 84 500 200 >1000
11 17 57 >500 340 >1000
19 0.38 79 400 500 >1000
12 23 33 400 500 >1000
20 17 47 340 300 >1000