Fig 2.

(A) Time course of glioma-associated antigen epitope-specific T-cell responses evaluated by interferon-γ enzyme-linked immunosorbent spot (ELISPOT) analyses in 15 patients who had samples available at week 0 (prevaccine) and at the week 6, 15, and 21 time points. Points represent net values after background subtraction. Patients who exhibited progression and did not have data at the week 15 or 21 time points are not shown. (B) ELISPOT results for patient 11, showing a dramatic response to interleukin 13 receptor alpha 2 (IL-13Rα2). The 12/11/10 scan from Figure 1 corresponds to time point A. High-dose steroids were started and the scan and symptoms rapidly and dramatically improved. ELISPOT positivity was diminished after initiation of high-dose dexamethasone (time point B), with subsequent recovery on weaning of dexamethasone.