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Effect of 4-AP on RPMI-8226 cells' voltage-gated potassium channel currents. (a) Current curve noted before and after 2 mM and 10 mM 4-AP treatment and 10 min washing. Stimulation procedure: currents were studied using a depolarizing pulse of 1 sec duration and 500 ms interval from −90 to +50 mV in 10 mV steps driven from a holding membrane potential of −80 mV. (b) Effect of 4-AP on voltage-current curve in RPMI-8226 cell line.
