Table 2.

Downregulated apoptosis-associated miRNAs in lung cancer.

MicroRNA	Target genes	Function	Cell lines	In vivo models	Citation
miR-7	BCL-2	Suppress cell proliferation and induce cell apoptosis Inhibit cancer cell migration in vitro  Reduce tumorigenicity in vivo	A549, NCI-H1299, NCI-H1355, NCI-H460, MRC-5, HEK-293T	Nude mice	[51]
miR-198	FGFR1	Inhibit lung cancer cells proliferation Enhance cell apoptosis Inhibits growth of tumor graft in nude mouse	A549, NCI-H460	Athymic BALB/c nude mice.	[69]
miR-451	RAB14	Inhibit in vitro proliferation and enhance apoptosis Decrease phosphorylation of AKT and increased BAX or Bad protein level Associated with in vivo proliferation capacity	A549, SPC-A1, NCI-H520	Athymic BALB/c nude mice.	[75]
miR-192	RB1	Inhibit cell proliferation and promotes cell apoptosis Arrest cell in G1 phase Inhibit tumorigenesis in vivo	A549, NCI-H460, 95D	Athymic BALB/c nude mice.	[76]
miR-335	BCL-W, SP1	Suppress proliferation and invasion ability of cells Induce apoptosis Suppress metastasis and invasiveness of cells	A549, NCI-H1299	N/T	[52]
miR-608	N/D	Increase cell death in Bcl-xL silenced cells	A549, SK-LU-1	N/T	[55]
miR-203	PKCα	Decrease cell proliferation Promote cell apoptosis, but this effect only partially relies on its downregulation of PKCα	A549	N/T	[61]
miR-413	PKCε	Inhibit cell proliferation and enhance apoptosis	A549, Calu-1	N/T	[63]
miR-146a	EGFR	Inhibit cell growth and induces cell apoptosis Suppress motility Enhance cell proliferation inhibitory effect of TKIs and cetuximab	NCI-H358, NCI-H1650, NCI-H1975, NCI-H292, HCC827	N/T	[70]
miR-26a	EZH2	Inhibit cell proliferation in vitroBlock G1/S phase transition and induced apoptosis Decreased metastasis capacity and invasion	SPC-A1, A549, SK-MES-1	N/T	[71]

N/D: not determined; N/T: not tested.