Table 1.
Clinicopathological correlation with LOH in HCC cases (cohort 1).
| Parameters | Genes | LOH/informative case | P value | |
|---|---|---|---|---|
| Age | ≤50 year | >50 year | ||
| ZDHHC2 | 12/17 | 5/21 | 0.004 | |
| TUSC3 | 10/16 | 7/18 | 0.169 | |
| MCPH1 | 11/17 | 9/20 | 0.231 | |
| KIAA1456 | 10/16 | 6/15 | 0.210 | |
|
| ||||
| Preoperative AFP level | ≤400 ng/mL | >400 ng/mL | ||
| ZDHHC2 | 4/15 | 13/23 | 0.070 | |
| TUSC3 | 5/12 | 12/22 | 0.473 | |
| MCPH1 | 6/14 | 14/23 | 0.286 | |
| KIAA1456 | 5/11 | 11/20 | 0.611 | |
|
| ||||
| Tumor number | Single | Multiple | ||
| ZDHHC2 | 4/15 | 13/23 | 0.070 | |
| TUSC3 | 5/12 | 12/22 | 0.473 | |
| MCPH1 | 4/14 | 16/23 | 0.015 | |
| KIAA1456 | 4/11 | 12/20 | 0.208 | |
|
| ||||
| Tumor size | ≤5 cm | >5 cm | ||
| ZDHHC2 | 6/23 | 11/15 | 0.004 | |
| TUSC3 | 9/22 | 8/12 | 0.151 | |
| MCPH1 | 9/22 | 11/15 | 0.052 | |
| KIAA1456 | 8/18 | 8/13 | 0.347 | |
|
| ||||
| PVTT | Absent | Present | ||
| ZDHHC2 | 11/31 | 6/7 | 0.031 | |
| TUSC3 | 14/29 | 3/5 | 1.000 | |
| MCPH1 | 14/30 | 6/7 | 0.097 | |
| KIAA1456 | 11/24 | 5/7 | 0.394 | |
|
| ||||
| Histopathologic grading | Well + moderately | Poorly | ||
| ZDHHC2 | 5/16 | 12/22 | 0.154 | |
| TUSC3 | 3/11 | 14/23 | 0.067 | |
| MCPH1 | 9/16 | 11/21 | 0.815 | |
| KIAA1456 | 5/14 | 11/17 | 0.108 | |
AFP: alpha-fetoprotein; PVTT: portal vein tumor thrombi.