Table 2.
Pharmacokinetics parameters of CoQ10 in rats after a single oral administration of CoQ10 suspension and nano-CoQ10 formulations modified with various surfactants.
| t 1/2 (h) | T max (h) | C max (μg/mL) | AUC0–48 h (μg/mL × h) | |
|---|---|---|---|---|
| Nano-CoQ10-TPGS | 17.37 ± 2.56 | 6 ± 0 | 1.49 ± 0.05⋆# | 30.38 ± 0.59⋆#§ |
| Nano-CoQ10-PHCO | 20.25 ± 1.23 | 7 ± 0 | 1.69 ± 0.05⋆ | 41.02 ± 0.47⋆ |
| Nano-CoQ10-PSAE | 21.01 ± 2.04 | 6 ± 0 | 1.74 ± 0.1⋆ | 39.81 ± 2.51⋆ |
| Nano-CoQ10-SP | 20.52 ± 2.78 | 6 ± 0 | 1.55 ± 0.15⋆ | 34.35 ± 2.58⋆# |
| Nano-CoQ10-SL | 18.52 ± 1.42 | 6 ± 0 | 1.35 ± 0.05⋆#§ | 26.7 ± 1.13⋆#§ |
| CoQ10-Suspension | 18.27 ± 3.71 | 6.33 ± 0.58 | 0.58 ± 0.02 | 11.47 ± 0.77 |
(n = 6, mean ± SD).
⋆ P < 0.01 versus CoQ10-Suspension.
# P < 0.05 versus nano-CoQ10-PHCO.
§ P < 0.05 versus Nano-CoQ10-SP.