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Effect on ACF incidence, number of ACFs, and size of polyps (adenomas) in DMH-induced colon cancer in rats.
| Groups | ACF incidence (%) | Polyps (adenomas) | ||||
|---|---|---|---|---|---|---|
| Number of ACFs/cm2
(mean ± SEM) |
Small (0.1–1 mm) |
Medium (2–4 mm) |
Large (5–8 mm) |
Total count |
||
| Control | 0 | 0 | 0 | 0 | 0 | 0 |
| DMH | 100.0 | 16.85 ± 1.5a | 4 | 5 | 4 | 13 |
| 5-FU | 100.0 | 11.6 ± 1.0a | 3 | 3 | 1 | 7 |
| IMF-8 | 100.0 | 12.5 ± 1.6a | 4 | 5 | 0 | 8 |
Values are reported as mean ± SEM of three readings in triplicate.
a P < 0.01 when compared to the control group.
