Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 23;205(6):829–846. doi: 10.1083/jcb.201403021

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Taylor et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 10. — Mechanism of Ca_Vβ_1a regulation of myogenesis. In Cacnb1^+/+ MPCs, Ca_Vβ_1a enters the nucleus and acts on an NC E-box on the Myog promoter, suppressing Myog expression and allowing Pax7⁺ MPCs to proliferate in sufficient quantity. Following differentiation cues, Ca_Vβ_1a exits the nucleus and Myog is disinhibited, allowing terminal differentiation and fusion of myotubes. In Cacnb1^−/− MPCs, Myog is not properly suppressed, leading to increased probability of Myog up-regulation and precocious differentiation. The number of myogenin-expressing cells is initially higher, but because their formation also depletes the Pax7⁺ progenitor pool, there are fewer precursors to form myogenin-positive cells at later time points. The final result is underdeveloped skeletal muscle.