Table II.

Estimated rate constants for the unified GPx kinetic model for different experimental data sets

	Flohé et al. [26] (H2O2)		Günzler et al. [34]						Forstrom et al. [36]
			(EthOOH)		(CumOOH)		(tBuOOH)		(CumOOH) Value	(LinOOH) Value
Parameter	Value	(S)*	Value	(S)	Value	(S)	Value	(S)
k1f (M−1 s−1)	6.7 × 107	0.47	3.7 × 107	0.57	1.5 × 107	0.64	6.2 × 106	0.59	5.5 × 106	2.11 × 107
k1r (s−1)	1 × 10−4	1 × 10−4	1 × 10−4	4 × 10−5	1 × 10−4	1 × 10−5	1 × 10−4	8 × 10−4	1 × 10−4	1 × 10−4
k2f (M−1 s−1)	1.4 × 108	0.15	1.3 × 108	0.17	1.25 × 108	0.15	1.2 × 108	0.18	6.4 × 107	8.4 × 107
k2r (s−1)	1 × 10−4	1 × 10−4	1 × 10−4	4 × 10−5	1 × 10−4	1 × 10−5	1 × 10−4	6 × 10−6	1 × 10−4	1 × 10−4
k3f (M−1 s−1)	1.0 × 108	0.22	9.6 × 107	0.24	9.8 × 107	0.2	1.0 × 108	0.21	7 × 106	7.4 × 106
k3r (s−1)a	1.7 × 10−3	N/A	8 × 10−4	N/A	3 × 10−4	N/A	1.3 × 10−4	N/A	5 × 10−6	2.9 × 10−5
k4f (s−1)	7.5 × 104	0.15	7.5 × 104	6 × 10−3	7.5 × 104	5 × 10−3	7.5 × 104	2 × 10−3	7.5 × 104	7.5 × 104
k4r (M−1 s−1)b	4.1 × 102	N/A	4.1 × 102	N/A	4.1 × 102	N/A	4.1 × 102	N/A	4.1 × 102	4.1 × 102
KH (M)	1.5 × 10−9	N/A	1.5 × 10−9	N/A	1.5 × 10−9	N/A	1.5 × 10−9	N/A	1.5 × 10−9	1.5 × 10−9
Keq (M−2)	1.0 × 1037	N/A	1.0 × 1037	N/A	1.0 × 1037	N/A	1.0 × 1037	N/A	8.2 × 1036	8.2 × 1036

N/A: Not applicable as they are fixed parameters.

^*(S)-Sensitivity.

^aParameter was calculated based on the thermodynamic constraint.

^bIndicates unidentifiable parameters for the respective data sets due to the absence of product inhibition data and fixed at a random value.