Table 1.

Enhancement of drug activity (MIC) with combination treatment.

Drug	Alone	In Combination	ΣFICb
c SB-P8B2	1 × MIC	0.1 X MIC	0.63
Rifampicin	1 × MIC	0.5 × MIC

^aMIC was determined by MABA

^bΣFIC is the sum of the FICs(MIC of a drug in combination/MIC of that drug alone) for all the drugs tested in the combination. Drugs are considered synergistic when the ΣFIC is less than 0.5 and antagonistic when the ΣFIC is greater than 4.

^cSB-P8B2, was used in combination with rifampicin as a representative of this novel class of FtsZ cell division inhibitors.