Table 2.

In vitro potency of SB-P8B2 and SB-P3G2 against non-replicating M. tuberculosis grown under low oxygen conditions.

	Concentration μg/mL	Log10 (CFU+/−SD)	Log10 (CFU) Reduction	% Viable Reduction
Control		5.35 ± 0.01	na	na
a Isoniazid	4	5.15 ± 0.2	0.2	36
	45	5.01 ± 0.32	0.34	54
b Metronidazole	4	4.83 ± 0.06	0.52	70
	45	3.39 ± 0.11	1.96	99
c SB-P8B2	4	4.96 ± 0.18	0.39	59
	45	4.38 ± 0.14	0.97	89
c SB-P3G2	4	4.87 ± 0.21	0.48	72

^aIsoniazid is not effective against non replicating bacteria.

^bMetronidazole is effective against non-replicating bacteria but has no efficacy against actively dividing bacteria.

^cRepresentative trisubstituted benzimidazoles.