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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Curr Opin Chem Biol. 2013 Jul 24;17(4):571–579. doi: 10.1016/j.cbpa.2013.06.020

Figure 3.

Figure 3

Working models accounting for the IspG-catalyzed reaction. (A) The epoxide model. According to this model, the epoxide (28) serves as a key intermediate. Once 28 is formed, two sequential single electron reduction steps lead to the formation of HMBPP (17). (B) Cation and organometallic models. In this case, the first step is the formation of a carbocation intermediate (31) by the C-O cleavage. Subsequent reductive dehydroxylation can proceed via either the radical cation intermediate (33) or the organometallic intermediate (34).