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Chromosome organization in E. coli BW25113 ΔtolC cells treated with 1 and 3. (a, c) Treatment of cells with both compounds produced filamentous cells. (b, d) DAPI labeled cells demonstrate that treatment with 3 produced compact chromosomes, whereas treatment with 1, known to induce dsDNA breaks, produced diffuse chromosomes. This experiment indicates differences in the mechanism of DNA gyrase inhibition by these two compounds.
