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. Author manuscript; available in PMC: 2014 Jun 24.
Published in final edited form as: Int J Obes (Lond). 2010 Nov 23;35(9):1173–1182. doi: 10.1038/ijo.2010.244

Table 3.

FTO SNP-by-ethnicity interaction P-values under the additive model comparing the IRAS cohort for SNPs historically associated with BMI

Adjusted for age, gender and admixturea
SNP × ethnicity P-value for BMI
SNP All ethnicities NHW vs HA NHW vs AA HA vs AA
rs1421085 2.7 × 10−3 0.23 0.015 6.9 × 10−4
rs1121980 0.035 0.46 0.051 0.012
rs17817449 8.1 × 10−3 0.13 0.065 1.9 × 10−3
rs8050136 1.5 × 10−3 0.14 0.018 3.4 × 10−4
rs3751812 5.2 × 10−4    0.075 0.016 1.0 × 10−4
rs9939609 7.8 × 10−3 0.10 0.084 1.8 × 10−3

Abbreviations: AA, African Americans; BMI, body mass index; HA, Hispanic Americans; IRAS, Insulin Resistance Atherosclerosis Study; NHW, non-Hispanic White Americans; SNP, single-nucleotide polymorphism.

a

Admixture adjustment uses separate ancestry estimates for Hispanics and African Americans as a covariate in the analysis. Numbers in bold indicate P-value ≤0.05 and numbers in italics indicate P-value ≤0.1.