FIG. 5.

Signature predicting dose at all times is visualized by multidimensional scaling. Axes represent the first three principal components of gene expression. Each point represents the relative expression of all 72 features in the signature (Supplementary Table S3) for an individual sample. The distance between any two points reflects their overall similarity of expression across all genes. The points are colored according to dose: 0 Gy (purple), 0.5 Gy (blue), 2 Gy (green), 5 Gy (orange) and 8 Gy (red). The shape of the symbols indicates the time after irradiation: 48 h (square), 24 h (open circle) and 6 h (closed circle).