Fig. 4.

Location of Aβ_1–40 in transgenic C. elegans strains. Representative images obtained in bright field (A, C, E) and by immunofluorescence analyses (B, D, F) of Aβ_1–40WT (A, B) and Aβ_1–40A2V-expressing worms (C, D). The 4G8 antibody immunostaining of worms expressing empty vector is reported in panel F. All animals are 2-day-old adults. A 4G8 positive signal (green) was observed in the head region (in the nerve ring area), ventral cord and lateral body wall neurons and in the tail ganglia (white arrows). Scale bar, 50 μm.