Table 5. Age-, race, and sex-adjusted hazard ratios (HR) and areas under the receiver-operating characteristic curves (AUC) for current American Society of Echocardiography (ASE)-recommended cut-points for left ventricular hypertrophy (LVH) and for 85th, 90th, and 95th percentile cut-points of left ventricular mass (LVM) index.
LVH parameter (unit) | LVH cut-point value | Prevalence of LVH (%) | HR (95% CI) | AUC (p-value) |
---|---|---|---|---|
LVM/ height2.7 (g/m2.7) | ||||
ASE-recommended | ≥49 M, ≥45 W | 378 (9.5) | 2.35 (1.51, 3.67) | 0.705 (NA) |
Liao,26 1997 (sex specific) | ≥ 50 M, 47 W | 299 (7.5) | 2.31 (1.44, 3.71) | 0.702 (0.55) |
Liao,26 1997 | ≥ 51 M/W | 216 (5.4) | 2.24 (1.33, 3.78) | 0.700 (0.51) |
95% Reference group (race-specific) | ≥44.6 B, ≥44.5 C | 551 (13.8) | 2.70 (1.84, 3.97) | 0.716 (0.16) |
85th Percentile | ≥45.1 M, ≥42.9 W | 587 (15.0) | 2.89 (1.98, 4.22) | 0.716 (0.20) |
90th Percentile | ≥47.3 M, ≥45.9 W | 399 (10.0) | 2.90 (1.93, 4.37) | 0.715 (0.07) |
95th Percentile | ≥51.6 M, ≥51.2 W | 200 (5.0) | 2.26 (1.32, 3.87) | 0.698 (0.39) |
LVM/BSA (g/m2) | ||||
ASE-recommended | ≥116 M, ≥96 W | 318 (8.0) | 2.53 (1.60, 4.01) | 0.706 (NA) |
Liao,26 1997 (sex specific) | ≥117 M, ≥104 W | 197 (5.0) | 2.26 (1.31, 3.90) | 0.699 (0.38) |
Liao,26 1997 | ≥ 125 M/W | 75 (1.9) | 2.34 (1.08, 5.08) | 0.698 (0.35) |
95% Reference group (race-specific) | ≥103.6 B, ≥104.5C | 395 (9.9) | 2.70 (1.76, 4.14) | 0.709 (0.77) |
85th Percentile | ≥105.4 M, ≥89.5 W | 598 (15.0) | 3.00 (2.06, 4.37) | 0.726 (0.08) |
90th Percentile | ≥111.1 M, ≥94.8 W | 399 (10.0) | 2.06 (1.31, 3.24) | 0.702 (0.31) |
95th Percentile | ≥119.4 M, ≥101.8 W | 200 (5.0) | 2.12 (1.21, 3.73) | 0.697 (0.25) |
Legend: LVM – left ventricular mass; BSA – body surface area; HR – hazard ratio; CI – confidence interval; NA – not applicable; M – men; W – women; B – blacks; C - caucasians. AUC p values refer to the difference in AUC from ASE-recommended cut-points.24