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. Author manuscript; available in PMC: 2014 Jun 24.
Published in final edited form as: J Immunol. 2013 Apr 29;190(11):5779–5787. doi: 10.4049/jimmunol.1200293

Figure 2.

Figure 2

Impaired Th2 protective immunity against H. bakeri infection in mice deficient in SerpinB2. WT or SerpinB2−/− mice were infected with H. bakeri (Hb). (A) Numbers of adult worms in the lumen of small intestine of C57BL/6 mice (WT) mice at day 14 post infection (DPI). qPCR was performed to measure the mRNA expression of (B) IL-13, (C) IL-4, (E) IL-13Rα2, (F) IL-25, and (G) IFNγ in the small intestine of mice at day 4, 7, 10, and 14 DPI. The fold changes were relative to the WT-vehicle (WT-VEH) groups after normalization to 18S rRNA. (D) ELISA analysis of the in situ IL-13 production of the intestines. **p<0.01 versus WT-Hb; *p<0.05 versus the respective VEH; ϕp<0.05 versus the respective WT (n≥5 for each group).